Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses of 1977-1978.
Identifieur interne : 002779 ( Main/Exploration ); précédent : 002778; suivant : 002780Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses of 1977-1978.
Auteurs : A S Beare ; A P Kendal ; N J Cox ; C. ScholtissekSource :
- Infection and Immunity [ 0019-9567 ] ; 1980.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de l'âge, Grippe humaine (microbiologie), Gènes viraux, Humains, Hémagglutinines virales (analyse), Recombinaison génétique, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Température, Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité).
- MESH :
- analyse : Hémagglutinines virales.
- génétique : Virus de la grippe A.
- immunologie : Virus de la grippe A.
- microbiologie : Grippe humaine.
- pathogénicité : Virus de la grippe A.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de l'âge, Gènes viraux, Humains, Recombinaison génétique, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Température.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Genes, Viral, Hemagglutinins, Viral (analysis), Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza, Human (microbiology), Middle Aged, Recombination, Genetic, Temperature.
- MESH :
- chemical , analysis : Hemagglutinins, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- microbiology : Influenza, Human.
- pathogenicity : Influenza A virus.
- Adolescent, Adult, Age Factors, Genes, Viral, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Middle Aged, Recombination, Genetic, Temperature.
Abstract
A series of trials was conducted in which wild-type A/USSR/90/77 (H1N1) influenza A virus and a few of its antigenic variants were inoculated into volunteers. Infections readily occurred in people of all ages who had initial low antibody titers, but clinical effects were generally mild in comparison with those of the previously tested subtypes, H0N1, H1N1, H2N2, H3N2. There was, however, an inverse relationship between severity of symptoms and age of volunteers, although the incidence of virus excretion and of increase in anti-hemagglutinin was apparently not age related. Naturally occurring recombinant viruses with H3 hemagglutinin and one or more genes of A/USSR/098/77-like strains were likewise studied in volunteers. These clones also produced mild symptoms, providing evidence of an attenuating effect on H3N2 viruses by the substitution of some of its genes with the genes of an H1N1 virus.
Url:
PubMed: 7399693
PubMed Central: 551014
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000324
- to stream Pmc, to step Curation: 000324
- to stream Pmc, to step Checkpoint: 000D82
- to stream PubMed, to step Corpus: 000590
- to stream PubMed, to step Curation: 000590
- to stream PubMed, to step Checkpoint: 000512
- to stream Ncbi, to step Merge: 001276
- to stream Ncbi, to step Curation: 001276
- to stream Ncbi, to step Checkpoint: 001276
- to stream Main, to step Merge: 002924
- to stream Main, to step Curation: 002779
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses of 1977-1978.</title><author><name sortKey="Beare, A S" sort="Beare, A S" uniqKey="Beare A" first="A S" last="Beare">A S Beare</name></author><author><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A P" last="Kendal">A P Kendal</name></author><author><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N J" last="Cox">N J Cox</name></author><author><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C" last="Scholtissek">C. Scholtissek</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">7399693</idno><idno type="pmc">551014</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC551014</idno><idno type="RBID">PMC:551014</idno><date when="1980">1980</date><idno type="wicri:Area/Pmc/Corpus">000324</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000324</idno><idno type="wicri:Area/Pmc/Curation">000324</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000324</idno><idno type="wicri:Area/Pmc/Checkpoint">000D82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D82</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:7399693</idno><idno type="wicri:Area/PubMed/Corpus">000590</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000590</idno><idno type="wicri:Area/PubMed/Curation">000590</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000590</idno><idno type="wicri:Area/PubMed/Checkpoint">000512</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000512</idno><idno type="wicri:Area/Ncbi/Merge">001276</idno><idno type="wicri:Area/Ncbi/Curation">001276</idno><idno type="wicri:Area/Ncbi/Checkpoint">001276</idno><idno type="wicri:doubleKey">0019-9567:1980:Beare A:human:trials:with</idno><idno type="wicri:Area/Main/Merge">002924</idno><idno type="wicri:Area/Main/Curation">002779</idno><idno type="wicri:Area/Main/Exploration">002779</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses of 1977-1978.</title><author><name sortKey="Beare, A S" sort="Beare, A S" uniqKey="Beare A" first="A S" last="Beare">A S Beare</name></author><author><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A P" last="Kendal">A P Kendal</name></author><author><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N J" last="Cox">N J Cox</name></author><author><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C" last="Scholtissek">C. Scholtissek</name></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="1980">1980</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Genes, Viral</term><term>Hemagglutinins, Viral (analysis)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza, Human (microbiology)</term><term>Middle Aged</term><term>Recombination, Genetic</term><term>Temperature</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de l'âge</term><term>Grippe humaine (microbiologie)</term><term>Gènes viraux</term><term>Humains</term><term>Hémagglutinines virales (analyse)</term><term>Recombinaison génétique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Température</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Hémagglutinines virales</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Genes, Viral</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Middle Aged</term><term>Recombination, Genetic</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de l'âge</term><term>Gènes viraux</term><term>Humains</term><term>Recombinaison génétique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A series of trials was conducted in which wild-type A/USSR/90/77 (H1N1) influenza A virus and a few of its antigenic variants were inoculated into volunteers. Infections readily occurred in people of all ages who had initial low antibody titers, but clinical effects were generally mild in comparison with those of the previously tested subtypes, H0N1, H1N1, H2N2, H3N2. There was, however, an inverse relationship between severity of symptoms and age of volunteers, although the incidence of virus excretion and of increase in anti-hemagglutinin was apparently not age related. Naturally occurring recombinant viruses with H3 hemagglutinin and one or more genes of A/USSR/098/77-like strains were likewise studied in volunteers. These clones also produced mild symptoms, providing evidence of an attenuating effect on H3N2 viruses by the substitution of some of its genes with the genes of an H1N1 virus.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Beare, A S" sort="Beare, A S" uniqKey="Beare A" first="A S" last="Beare">A S Beare</name><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N J" last="Cox">N J Cox</name><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A P" last="Kendal">A P Kendal</name><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C" last="Scholtissek">C. Scholtissek</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002779 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002779 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:551014
|texte= Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses of 1977-1978.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:7399693" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |